An insight into Feline Limbic Encephalitis
Feline limbic encephalitis or Feline complex partial cluster seizure with orofacial involvement (FEPSO) is a suspected immune-mediated condition of geriatric cats. In people, limbic encephalitis is associated with the production of serum antibodies against voltage-gated potassium channel complexes (VGKC-complexes) resulting in an acute epileptic condition. In a study of 14 cats suffering distinctive complex partial cluster seizures (CPS), consisting of facial twitching and staring, 5/14 cats had VGKC-complex antibodies and 4/14 cats had leucine-rich glioma-inactivated 1 (LGI1)-antibodies (Pakozdy et al, 2013).