Paraneoplastic syndromes (PS) are frequently the first manifestations of tumors due to the production and release of biologically active molecules such as hormones, cytokines, peptides, and growth factors by tumor cells. Paraneoplastic disorders are common in human cancer patients, but there is a lack of knowledge about these diseases in animals. Cases of Paraneoplastic syndromes have also been reported in dogs and cats. However, these diseases have been diagnosed too late, after the identification of cancer. Thus, recognizing PS early on provides the opportunity to treat cancer successfully. PS occur distant from the tumor site and can be identified as a systemic disorder.  

One of the tumor manifestations are Paraneoplastic Neurological disorders or Paraneoplastic Neurological Syndromes (PNS), which are the result of an indirect effect of the tumor on the nervous system and can appear before tumor identification with the ability to affect any part of the nervous system. Case reports demonstrate the effect of various tumor types on the brain and spinal cord. PNS signs included acute limb paralysis, progressive loss of motor function, lack of coordination, loss of superficial and deep pain sensation over limbs, development of diencephalic syndrome, development of cerebellar degeneration, and more. PNS signs are typically related to auto-immune stimulation and the production of autoantibodies to specific substances. These autoantibodies, also called onconeural or high-risk, produced against some neuronal antigens, have been identified in serum and cerebrospinal fluid even before any cancer manifestations.  

However, onconeural antibodies are specific to malignancy rather than a particular neurological syndrome and can be found without diagnosing one. 

Therefore, the detection of these autoantibodies can help with early cancer diagnosis, finding adequate treatment, and avoiding unnecessary expansive procedures.  

This test is the only one on the veterinary market that differentiates twenty-two different tumors and fourteen neurological diseases and is available for felines too. Dogs and cats with and without clinical signs should be screened for these diseases to detect possible tumours at a treatable stage. The test is an excellent tool to confirm or decline suspicion of having one of 22 tumors and to monitor post-treatment. 

• The first Early Cancer Diagnostic test for all webinar participants is discounted 20% 

• The first 10ᵗʰ Early Cancer Diagnostic test that we receive from you within one calendar month will be free of charge). Onetime offer 

• Thereafter, every 10ᵗʰ Early Cancer diagnostic test received from your hospital within one calendar month will be discounted by 25%. This is a lifetime offer 

• For every new referral, your clinic and your referral clinic will receive a 10% discount (your next test and their first test). This is a lifetime offer as well. 

Khristofor Agassandian 

+1 (470)461-1655; [email protected]